学术报告:Designing Janus Biointerfaces to Interrogate Immune Functions

2019/05/15 | 【 【打印】【关闭】 | 访问次数:
报告题目:Designing Janus Biointerfaces to Interrogate Immune Functions

报 告 人:Yan Yu (Indiana University-Bloomington)



Understanding and controlling the response of immune cells holds great promise for the
development of precision medicine, particularly for cancer immunotherapy. Functions of
immune cells are known to depend on the intricately organized chemical reactions and
physical forces. Examples range from the engulfment of invading bacteria that relies on
a fine balance of competing mechanical forces, to the activation of T-lymphocytes that
requires collective interactions between thousands of receptors at the junction between
cells. Owing to the complexity of these processes, understanding immune functions
using traditional biological tools is highly challenging. In this talk, I will present my
group’s research progress towards designing unique biointerfaces to enable the
quantitative understanding and manipulation of immune functions. Our research so far
has capitalized on Janus particles, which, like the two-faced Roman god Janus, are
made chemically, biologically, optically or magnetically asymmetric. We developed
Janus particle-based toolsets for measuring cell dynamics in multi-dimensions beyond
translational motion and for spatiotemporally controlling cell functions. Using these
methods, we uncovered new mechanisms in immune regulation and achieve
spatiotemporal control of immune processes, from phagocytosis to intracellular
trafficking, which would otherwise be difficult to access with traditional means.


Prof. Yan Yu is an Associate Professor in the Department of Chemistry at Indiana
University Bloomington. She received her B.S. in Chemistry from Peking University
(Beijing, China) in 2004, and Ph.D. in Materials Science and Engineering at the
University of Illinois-Urbana Champaign in 2009 under the direction of Prof. Steve
Granick. She completed her postdoctoral training with Prof. Jay T. Groves at the
University of California at Berkeley from 2009 to 2012. Since starting her independent
career in July 2012, Prof. Yan Yu has received numerous awards, including CAREER
award from the National Science Foundation (2016), the Cottrell Scholar Award from
the Research Corporation for Science Advancement (2016), and the Maximizing
Investigators’ Research Award from the National Institutes of Health (2017). She was
named a Sloan Fellow in 2017 by the Alfred P. Sloan Foundation.